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大鼠结肠改道后组织学变化的预防：一项实验研究。

Prevention of Histological Changes after Colonic Diversion in Rats: An Experimental Study.

作者信息

M Pathak, M Srinivas, A Shariff

机构信息

Department of Pediatric Surgery, All India Institute of Medical Sciences, Jodhpur, 342001, India.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.

出版信息

J Neonatal Surg. 2017 Apr 15;6(2):26. doi: 10.21699/jns.v6i2.511. eCollection 2017 Apr-Jun.

DOI:10.21699/jns.v6i2.511
PMID:28770123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5538592/
Abstract

AIM

To determine the beneficial effects of Glutamine, Psyllium, Short Chain Fatty Acids (SCFA), and Maharishi Amrit Kalash (MAK), in preventing the histological changes after diversion colostomy.

MATERIAL AND METHODS

After ethical clearance, male wistar rats (n=40) underwent diversion colostomy. Rats were divided into five groups of 8 rats each. Each group was given, after diversion colostomy, per rectally, one of the five agents being tested as an enema (3 ml/kg/day). Group I: Normal saline. Group II: Glutamine Group III: Psyllium, Group IV: MAK. Group V: Short chain fatty acid. The rats were euthanised 45 days after performing diversion colostomy. Morphometrical analysis of defunctionalised colon was done. Statistical analysis was done using SSPS statistical analysis software.

RESULTS

On comparison with Group I epithelial cell height and mucosal thickness was significantly higher in Group II. Muscularis externae thickness was significantly higher in Group III on comparison with Group I. Group V had least inflammatory changes.

CONCLUSIONS

Atrophic and inflammatory changes in the diverted colon can be prevented by per rectal administration of Glutamine, Psyllium and Short chain fatty acids.

摘要

目的

确定谷氨酰胺、车前子、短链脂肪酸（SCFA）和玛赫西阿姆里特卡拉什（MAK）在预防转流性结肠造口术后组织学变化方面的有益作用。

材料与方法

经伦理批准后，对雄性Wistar大鼠（n = 40）实施转流性结肠造口术。将大鼠分为五组，每组8只。转流性结肠造口术后，每组经直肠给予五种受试药物之一作为灌肠剂（3毫升/千克/天）。第一组：生理盐水。第二组：谷氨酰胺。第三组：车前子。第四组：MAK。第五组：短链脂肪酸。转流性结肠造口术后45天对大鼠实施安乐死。对失功能结肠进行形态计量分析。使用SSPS统计分析软件进行统计分析。

结果

与第一组相比，第二组的上皮细胞高度和黏膜厚度显著更高。与第一组相比，第三组的外肌层厚度显著更高。第五组的炎症变化最少。

结论

经直肠给予谷氨酰胺、车前子和短链脂肪酸可预防转流结肠的萎缩和炎症变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/5f1930ea11cd/JNS-6-26_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/e41ecbda5266/JNS-6-26_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/44d1de9b2d07/JNS-6-26_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/5f1930ea11cd/JNS-6-26_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/e41ecbda5266/JNS-6-26_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/44d1de9b2d07/JNS-6-26_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/5538592/5f1930ea11cd/JNS-6-26_F3.jpg

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Effects of a Glutamine Enema on Anastomotic Healing in an Animal Colon Anastomosis Model.谷氨酰胺灌肠剂对动物结肠吻合模型吻合口愈合的影响。
Ann Coloproctol. 2015 Dec;31(6):213-21. doi: 10.3393/ac.2015.31.6.213. Epub 2015 Dec 31.
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Pathophysiology, clinical presentation and management of diversion colitis: a review of current literature.分流性结肠炎的病理生理学、临床表现和治疗：对现有文献的综述。
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Effects of oral supplement of L-glutamine on diverted colon wall.口服补充L-谷氨酰胺对旷置结肠壁的影响。
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