Groisman S D, Krasilschikov K B
J Auton Nerv Syst. 1986 Sep;17(1):33-44. doi: 10.1016/0165-1838(86)90042-1.
The aim of this study was to investigate the effects of catecholamines on motility of stomach and intestine in chronic experiments on dogs with fistulas in stomach and duodenum. The contractions of stomach and duodenum were registered by a balloon method. It was established that i.v. adrenaline and noradrenaline injections in dogs with intact vagi inhibited food-induced motility in stomach and duodenum and did not produce contractions in the empty and quiescent gastrointestinal tract. Beta-adrenoagonist isoprenaline on the contrary produced stomach and duodenum contractions in fed dogs during the quiescent period. In fed dogs isoprenaline caused a 3-phasic reaction: a phase of primary short-term suppression of stomach and duodenum motility, a phase of motility increase and a phase of secondary suppression of stomach and duodenum motility. The contractions evoked by isoprenaline in the stomach resemble in amplitude and shape, periodical activities which are typical for fasting dogs. Vagotomy intensified isoprenaline motor effects in hungry and fed dogs and eliminated the phase of primary suppression in fed dogs. The isoprenaline effects were blocked by propranolol, but not by phentolamine. They were decreased more effectively in the stomach by atropine and by hexomethonium in the duodenum.
本研究的目的是在患有胃和十二指肠瘘管的犬的慢性实验中，研究儿茶酚胺对胃和肠道运动的影响。胃和十二指肠的收缩通过气囊法记录。结果表明，在迷走神经完整的犬中静脉注射肾上腺素和去甲肾上腺素会抑制食物诱导的胃和十二指肠运动，并且在空腹和静止的胃肠道中不会产生收缩。相反，β-肾上腺素能激动剂异丙肾上腺素在喂食犬的静止期会引起胃和十二指肠收缩。在喂食犬中，异丙肾上腺素会引起三相反应：胃和十二指肠运动的初级短期抑制期、运动增加期和胃和十二指肠运动的次级抑制期。异丙肾上腺素在胃中引起的收缩在幅度和形状上类似于空腹犬典型的周期性活动。迷走神经切断术增强了饥饿和喂食犬中异丙肾上腺素的运动效应，并消除了喂食犬中的初级抑制期。异丙肾上腺素的作用可被普萘洛尔阻断，但不能被酚妥拉明阻断。在胃中，阿托品能更有效地降低异丙肾上腺素的作用，在十二指肠中，六甲溴铵能更有效地降低其作用。
