Yamada K, Iizuka M
Nihon Heikatsukin Gakkai Zasshi. 1983 Feb;19(1):25-35.
Responses of the gastric antrum and duodenum to some drugs were studies in fasted state of conscious dogs using implanted force transducer and/or electrodes. Continuous i.v. infusion of pentagastrin (12-30 micrograms/kg-hr), secretin (1.8 u/kg-hr) and atropine (30-120 micrograms/kg-hr) suppressed the development of the interdigestive myoelectric complex or the interdigestive contractions. During infusion of atropine or secretin, action potentials superimposed on basic electric rhythm (BER) and contractions were frequently observed in the duodenum in spite of motor quiescence in the antrum. A bolus i.v. injection of bethanechol (10-20 micrograms/kg) clearly produced action potentials and contractions in the duodenum, while, in the antrum, only a few contractions were observed. Pentagastrin (12-30 micrograms/kg-hr, 5-10 micrograms/kg i.v.) induced weak but high-frequency contractions in the antrum, whereas, in the duodenum, contractions were scarcely observed except the case of the infusion of the drug over 30 min. The drug also changed the frequency and amplitude of BER remarkably in both regions. Phentolamine (3.0-6.0 mg/kg-hr, 1.0-1.5 mg/kg i.v.) introduced strong contractions similar to the interdigestive contractions. The result indicates that diminution of the adrenergic nerve activity of the myenteric plexus is one of the factors participating in occurrence of the interdigestive contractions.
在清醒的空腹犬中，使用植入式力传感器和/或电极，研究了胃窦和十二指肠对某些药物的反应。持续静脉输注五肽胃泌素（12 - 30微克/千克·小时）、促胰液素（1.8单位/千克·小时）和阿托品（30 - 120微克/千克·小时）可抑制消化间期肌电复合波或消化间期收缩的发展。在输注阿托品或促胰液素期间，尽管胃窦处于运动静止状态，但十二指肠中经常观察到叠加在基本电节律（BER）上的动作电位和收缩。静脉推注氨甲酰甲胆碱（10 - 20微克/千克）可在十二指肠中明显产生动作电位和收缩，而在胃窦中仅观察到少数收缩。五肽胃泌素（12 - 30微克/千克·小时，静脉注射5 - 10微克/千克）可在胃窦中诱发微弱但高频的收缩，而在十二指肠中，除了输注该药物超过30分钟的情况外，几乎观察不到收缩。该药物还显著改变了两个区域BER的频率和幅度。酚妥拉明（静脉注射3.0 - 6.0毫克/千克·小时，1.0 - 1.5毫克/千克）引发了类似于消化间期收缩的强烈收缩。结果表明，肠肌丛肾上腺素能神经活动的减弱是参与消化间期收缩发生的因素之一。
