用四正丁基氟化铵催化活化的碳化钙用于Sonogashira交叉偶联反应。

Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions.

作者信息

Hosseini Abolfazl, Pilevar Afsaneh, Hogan Eimear, Mogwitz Boris, Schulze Anne S, Schreiner Peter R

机构信息

Institute of Organic Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.

出版信息

Org Biomol Chem. 2017 Aug 16;15(32):6800-6807. doi: 10.1039/c7ob01334e.

DOI:10.1039/c7ob01334e

PMID:28770930

Abstract

We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.

摘要

我们报道了一种利用催化活化的碳化钙作为炔烃组分直接合成单芳基化和双芳基化炔烃的新方法。这种氟化物活化的交叉偶联反应在操作简便性、使用易得的起始原料和低成本方面比现有方法具有优势。