Department of Neurosurgery, Affiliated Xuzhou Hospital of Southeast University, Xuzhou, Jiangsu Province, China.
Eur Rev Med Pharmacol Sci. 2017 Jul;21(14):3207-3211.
The glioblastoma includes brain tumors, which are very aggressive in nature and are among the most common brain tumors in adults. Latest therapeutic avenues involve combination approach. However, the observed median survival is still no more than 15 months. Moreover, there is a scarcity of accurate pre-clinical model systems, which in turn resulted in limited treatment options for this disease. Cancer stem cells are attractive avenues in anticancer research against glioblastoma. Most of the recent studies are focused towards the identification of novel markers for cancer stem cells. The present review article is focused on two important markers in current research viz. Prominin-1 and NPM1 in glioblastoma.
胶质母细胞瘤包括脑肿瘤，其性质非常具有侵袭性，是成人中最常见的脑肿瘤之一。最新的治疗方法包括联合治疗。然而，观察到的中位生存期仍不超过 15 个月。此外，缺乏准确的临床前模型系统，这反过来又导致这种疾病的治疗选择有限。癌症干细胞是针对胶质母细胞瘤的抗癌研究的一个有吸引力的途径。大多数最近的研究都集中在鉴定癌症干细胞的新标志物上。本文综述重点关注当前研究中的两个重要标志物，即 Prominin-1 和 NPM1 在胶质母细胞瘤中的作用。
