Kor-Anantakul Ounjai, Suntharasaj Thitima, Suwanrath Chitkasaem, Hanprasertpong Tharangrut, Pranpanus Savitree, Pruksanusak Ninlapa, Janwadee Suthiraporn, Geater Alan
Department of Obstetrics and Gynaecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Epidemiology Unit2, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
PLoS One. 2017 Aug 3;12(8):e0182538. doi: 10.1371/journal.pone.0182538. eCollection 2017.
To establish normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in southern Thai women, and to compare these reference levels with Caucasian-specific and northern Thai models.
A cross-sectional study was conducted in 1,150 normal singleton pregnancy women to determine serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG) concentrations in women from southern Thailand. The predicted median values were compared with published equations for Caucasians and northern Thai women.
The best-fitting regression equations for the expected median serum levels of PAPP-A (mIU/L) and free β- hCG (ng/mL) according to maternal weight (Wt in kg) and gestational age (GA in days) were: [Formula: see text] and [Formula: see text] Both equations were selected with a statistically significant contribution (p< 0.05). Compared with the Caucasian model, the median values of PAPP-A were higher and the median values of free β-hCG were lower in the southern Thai women. And compared with the northern Thai models, the median values of both biomarkers were lower in southern Thai women.
The study has successfully developed maternal-weight- and gestational-age-adjusted median normative models to convert the PAPP-A and free β-hCG levels into their Multiple of Median equivalents in southern Thai women. These models confirmed ethnic differences.
建立泰国南部女性孕早期21三体综合征血清生物标志物中位数水平的体重校正模型，并将这些参考水平与白种人特异性模型及泰国北部模型进行比较。
对1150例正常单胎妊娠女性进行横断面研究，以确定泰国南部女性血清妊娠相关血浆蛋白A（PAPP-A）和游离β-人绒毛膜促性腺激素（β-hCG）浓度。将预测的中位数与已发表的白种人和泰国北部女性的方程进行比较。
根据孕妇体重（Wt，单位为kg）和孕周（GA，单位为天），PAPP-A（mIU/L）和游离β-hCG（ng/mL）预期血清中位数水平的最佳拟合回归方程分别为：[公式：见原文]和[公式：见原文]。两个方程均具有统计学显著贡献（p<0.05）。与白种人模型相比，泰国南部女性PAPP-A的中位数较高，游离β-hCG的中位数较低。与泰国北部模型相比，泰国南部女性两种生物标志物的中位数均较低。
本研究成功建立了根据孕妇体重和孕周校正的中位数规范模型，以将泰国南部女性的PAPP-A和游离β-hCG水平转换为中位数倍数等效值。这些模型证实了种族差异。
