Centre for Clinical Research in Neuropsychiatry (CCRN), School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth WA 6000, Australia; Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology, Samara State Medical University, Samara, Russia.
Centre for Clinical Research in Neuropsychiatry (CCRN), School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth WA 6000, Australia.
Psychiatry Res. 2017 Nov;257:203-211. doi: 10.1016/j.psychres.2017.07.044. Epub 2017 Jul 25.
Deficits in action (verb) fluency have previously been reported in schizophrenia spectrum disorders. The degree to which this reflects difficulties generating verbs in different semantic categories is unknown. Here, action fluency responses of 46 patients with schizophrenia spectrum disorders and 76 healthy controls were classified as action or mental state verbs, using well-established taxonomies. The word length, frequency, age of acquisition, valence and concreteness of the verbs produced were also examined. Participants also completed measures of cognitive function, and clinical symptoms. Independent inter-rater agreement of semantic categorization was high. The percentage of action verbs produced was significantly lower in patients than controls, whilst the percentage of mental state verbs produced did not differ. Patients' action verbs were: significantly less concrete; positively correlated with memory and intelligence; and negatively correlated with interpersonal symptoms. Impaired action verb, but intact mental state verb generation is consistent with the neural separability of these processes.
在精神分裂症谱系障碍中，以前曾报道过动作（动词）流畅性缺陷。目前尚不清楚这在多大程度上反映了在不同语义类别中生成动词的困难。在这里，使用成熟的分类法，将 46 名精神分裂症谱系障碍患者和 76 名健康对照者的动作流畅性反应分为动作动词或心理状态动词。还检查了产生的动词的词长、频率、习得年龄、词义和具体性。参与者还完成了认知功能和临床症状的测量。语义分类的独立评分者间一致性很高。与对照组相比，患者产生的动作动词的百分比明显更低，而产生的心理状态动词的百分比则没有差异。患者的动作动词：明显不具体；与记忆和智力呈正相关；与人际关系症状呈负相关。动作动词生成受损而心理状态动词生成正常，这与这些过程的神经可分离性一致。
