阿尔茨海默病患者动词流畅性的聚类和切换分析。
Clustering and switching analysis of verb fluency in individuals with Alzheimer's disease.
机构信息
Departamento de Fonoaudiologia, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA - Porto Alegre (RS), Brasil.
Programa de Pós-graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA - Porto Alegre (RS), Brasil.
出版信息
Codas. 2023 Apr 17;35(2):e20210179. doi: 10.1590/2317-1782/20232021179pt. eCollection 2023.
PURPOSE
To investigate verb fluency performance in individuals with Alzheimer's disease compared with healthy older adults by analyzing total correct responses, number of clusters, average cluster size, and number of switches.
METHODS
This is a case-control study of 39 healthy older adults and 29 older adults with a diagnosis of Alzheimer's disease. Verb fluency performance was analyzed in terms of total number of correct verbs retrieved, number of clusters, average cluster size, and number of switches. To obtain the study outcomes, we previously conducted a procedure for categorization of the verbs that would compose the clusters. The classification of verbs was adapted for this study, including assessment by raters and analysis of inter-rater reliability.
RESULTS
Individuals with Alzheimer's disease showed significantly poorer performance than healthy controls in the number of switches and total number of correct verbs retrieved. The two groups did not differ significantly in the other measures.
CONCLUSION
In this study, individuals with Alzheimer's disease showed impaired verb fluency, characterized by a reduced number of verbs retrieved and fewer transitions between verb categories. The findings suggest that, in Alzheimer's disease, verb fluency is more sensitive to cognitive deficits resulting from executive dysfunction than from semantic disruption.
目的
通过分析总正确反应数、聚类数、平均聚类大小和转换次数，研究阿尔茨海默病患者与健康老年人的动词流畅性表现。
方法
这是一项病例对照研究，共纳入 39 名健康老年人和 29 名被诊断为阿尔茨海默病的老年人。动词流畅性表现通过检索到的正确动词总数、聚类数、平均聚类大小和转换次数进行分析。为了获得研究结果，我们之前进行了一个动词聚类分类程序。动词的分类适应了本研究，包括评估者的评估和内部一致性信度分析。
结果
与健康对照组相比，阿尔茨海默病患者在转换次数和检索到的总正确动词数方面表现明显较差。两组在其他测量指标上没有显著差异。
结论
在这项研究中，阿尔茨海默病患者表现出动词流畅性受损，表现为检索到的动词数量减少，动词类别之间的转换次数减少。这些发现表明，在阿尔茨海默病中，动词流畅性对执行功能障碍引起的认知缺陷比语义障碍更敏感。
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