Iacono Marcello, Connolly Damian, Heise Andreas
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
Department of Science, Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Cork Road, Waterford, Ireland.
Materials (Basel). 2016 Mar 31;9(4):263. doi: 10.3390/ma9040263.
Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths.
聚合物是用于制造廉价整体色谱和固相萃取（SPE）装置的有趣的外壳材料。当在较大直径的非锥形圆柱形管中形成聚合物整体时，会出现挑战，因为整体可能会从外壳壁上分离，导致分离性能和机械稳定性丧失。在此，采用两步法确保在直径为2.0毫米的聚丙烯（PP）管中形成坚固的均相甲基丙烯酸酯整体。详细的傅里叶变换红外（FTIR）光谱分析和扫描电子显微镜（SEM）成像证实了通过交联二甲基丙烯酸乙二酯（EDMA）的锚固层成功对管壁进行了预改性。随后在PP管中形成EDMA-甲基丙烯酸缩水甘油酯（GMA）整体，与未锚固的整体相比，得到了具有增强机械稳定性的均相整体聚合物。
