Kavaliers M, Hirst M
Life Sci. 1986 Nov 10;39(19):1729-35. doi: 10.1016/0024-3205(86)90091-3.
The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice. PLG (0.01-10 mg/Kg) reduced, in a dose-dependent manner, the incidence and intensity of offensive aggression in dominant resident mice. PLG was more potent than naloxone (1.0 mg/Kg). In a number of cases, PLG completely eliminated the display of offensive aggression towards intruder mice. These results raise the possibility that PLG may function as an "anti-aggressive" peptide whose actions may include antagonistic and/or modulatory influences on both opioid and non-opioid systems.
研究了内源性肽-亮氨酰甘氨酰胺（PLG，巨噬细胞移动抑制因子-1）和外源性阿片拮抗剂纳洛酮对雄性小鼠攻击性行为的影响。PLG（0.01-10毫克/千克）以剂量依赖性方式降低了占主导地位的常驻小鼠攻击性行为的发生率和强度。PLG比纳洛酮（1.0毫克/千克）更有效。在许多情况下，PLG完全消除了对入侵小鼠的攻击性行为表现。这些结果增加了PLG可能作为一种“抗攻击”肽发挥作用的可能性，其作用可能包括对阿片类和非阿片类系统的拮抗和/或调节影响。
