Symes Richard J, Mikelberg Frederick S
University of British Columbia, The Eye Care Centre, Vancouver, B.C.
University of British Columbia, The Eye Care Centre, Vancouver, B.C.
Can J Ophthalmol. 2017 Aug;52(4):361-365. doi: 10.1016/j.jcjo.2016.12.008. Epub 2017 Feb 20.
The aim of this study was to investigate contemporary practice patterns with respect to normal tension glaucoma (NTG) management and to determine whether the 2 largest NTG trials have influenced ophthalmologists' clinical practice.
A survey questionnaire was sent to ophthalmologists via the American Glaucoma Society, the Canadian Glaucoma Society, and the Canadian Ophthalmological Society. The questionnaire was designed to investigate ophthalmologists' usual practice with respect to NTG and the extent to which practice has been influenced by the Collaborative Normal Tension Glaucoma Study (CNTGS) and the Low pressure Glaucoma Treatment Study (LoGTS).
In total, 419 ophthalmologists completed the survey. Of these, 264 respondents were glaucoma subspecialists. The survey showed that 95% and 64% of ophthalmologists were familiar with the CNTGS and the LoGTS, respectively. Of the respondents, 70% indicated that they would initiate treatment in mild-to-moderate NTG without waiting for documented disease progression. Of the respondents, 61% of the total surveyed and 50% of the glaucoma subspecialists felt that the LoGTS results had no impact on their usual clinical practice. The first-choice topical drug for NTG was a prostaglandin analogue (88% of respondents) or brimonidine (10% of respondents).
Most ophthalmologists treat NTG more aggressively than recommended by the CTNGS protocol. Most ophthalmologists felt that the LoGTS results had no impact on their normal clinical practice. The prostaglandin analogues are, by far, the most popular choice of drug for contemporary management of NTG.
本研究旨在调查正常眼压性青光眼(NTG)管理的当代实践模式,并确定两项最大规模的NTG试验是否影响了眼科医生的临床实践。
通过美国青光眼协会、加拿大青光眼协会和加拿大眼科协会向眼科医生发送调查问卷。该问卷旨在调查眼科医生对NTG的常规诊疗方法,以及其诊疗受到协作性正常眼压性青光眼研究(CNTGS)和低压青光眼治疗研究(LoGTS)影响的程度。
共有419名眼科医生完成了调查。其中,264名受访者是青光眼专科医生。调查显示,分别有95%和64%的眼科医生熟悉CNTGS和LoGTS。在受访者中,70%表示他们会在轻度至中度NTG患者中开始治疗,而不会等待记录到疾病进展。在受访者中,61%的总体受访者和50%的青光眼专科医生认为LoGTS的结果对他们的常规临床实践没有影响。NTG的首选局部用药是前列腺素类似物(88%的受访者)或溴莫尼定(10%的受访者)。
大多数眼科医生治疗NTG的方式比CNTGS方案推荐的更为积极。大多数眼科医生认为LoGTS的结果对他们的正常临床实践没有影响。到目前为止,前列腺素类似物是当代NTG管理中最受欢迎的药物选择。