Andrei Graciela, Carter Kara, Janeba Zlatko, Sampath Aruna, Schang Luis M, Tarbet E Bart, Vere Hodge R Anthony, Bray Mike, Esté José A
KU Leuven, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Sanofi, 270 Albany Street, Cambridge, MA 02139, USA.
Antiviral Res. 2017 Sep;145:184-196. doi: 10.1016/j.antiviral.2017.07.017. Epub 2017 Aug 1.
The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of the most important accomplishments in recent drug discovery in antiviral research, the identification of the hepatitis C virus direct-acting antiviral sofosbuvir and new alternatives to combat hepatitis B virus (HBV) infection. The Antonín Holý Lecture Award by David Chu on medicinal chemistry provided an overview of early developments of nucleoside analogs for the treatment of HIV and varicella zoster virus infection and how this knowledge serves to develop new drugs targeting HBV. Priscilla Yang gave the first ISAR Women in Science lecture. She reported on pharmacological validation of new antiviral targets for dengue, Zika and other flaviviruses. The William Prusoff Young Investigator Lecture Award by Maaike Everts described the Alabama Drug Discovery Alliance and the Antiviral Drug Discovery and Development Consortium, and how they are helping to accelerate the development of new antivirals. The 30th ICAR was a success in promoting new discoveries in antiviral drug development and research. The 31st ICAR will be held in Porto, Portugal, June 11-15, 2018.
第30届国际抗病毒研究会议(ICAR)于2017年5月18日至21日在美国佐治亚州亚特兰大举行。本报告介绍了会议期间的获奖讲座、特邀主题演讲和口头报告。迈克尔·索菲亚颁发的2017年格特鲁德·埃利恩纪念讲座奖强调了抗病毒研究中近期药物发现的一项最重要成就,即丙型肝炎病毒直接作用抗病毒药物索磷布韦的鉴定以及对抗乙型肝炎病毒(HBV)感染的新替代药物。大卫·朱颁发的安东宁·霍利讲座奖关于药物化学,概述了用于治疗HIV和水痘带状疱疹病毒感染的核苷类似物的早期发展情况,以及这些知识如何用于开发针对HBV的新药。普莉西拉·杨发表了首届ISAR女性科学讲座。她报告了登革热、寨卡病毒和其他黄病毒新抗病毒靶点的药理学验证情况。马艾克·埃弗茨颁发的威廉·普鲁索夫青年研究者讲座奖介绍了阿拉巴马药物发现联盟和抗病毒药物发现与开发联盟,以及它们如何帮助加速新抗病毒药物的开发。第30届ICAR在促进抗病毒药物开发和研究的新发现方面取得了成功。第31届ICAR将于2018年6月11日至15日在葡萄牙波尔图举行。