Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran.
Center for Nanofibers and Nanotechnology and Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore.
J Control Release. 2017 Sep 28;262:317-328. doi: 10.1016/j.jconrel.2017.07.041. Epub 2017 Jul 31.
Glass-ionomer cements (GICs) have been widely used for over forty years, because of their desirable properties in dentistry. The most important advantages of the GICs are associated with their ability to release long-term antimicrobial agents. However, GICs used as restorative materials have still lots of challenges due to their secondary caries and low mechanical properties. Recent studies showed that the fluoride-releasing activity of conventional GICs is inadequate for effectual antibacterial conservation in many cases. Therefore, many efforts have been proposed to modify the antibacterial features of GICs in order to prevent the secondary caries. Particularly, for achieving this goal GICs were incorporated into various biomaterials possessing antibacterial activities. The scope of this review is to assess systematically the extant researches addressing the antibacterial modifications in GICs in order to provide with an authoritative, at the same time in-depth understanding of controlled antibacterial release in this class of biomaterials. It also gives a whole perspective on the future developments of GICs and challenges related to antibacterial GICs.
玻璃离子水门汀（GICs）在口腔医学领域已广泛应用四十余年，因其具有独特的性能。GICs 的最重要的优点与其能够长期释放抗菌剂有关。然而，GICs 作为修复材料仍存在诸多挑战，主要是继发龋和机械性能低。最近的研究表明，在许多情况下，传统 GICs 的氟释放活性不足以有效保持抗菌效果。因此，人们提出了许多改进 GICs 抗菌性能的方法，以防止继发龋。特别是，为了实现这一目标，GICs 被掺入具有抗菌活性的各种生物材料中。本文旨在系统评估现有研究，以了解 GICs 的抗菌改性，为深入了解该类生物材料的抗菌释放提供权威性认识。本文还综述了 GICs 的未来发展和抗菌 GICs 面临的挑战。
