Abrahamson M J, Millar R P
S Afr Med J. 1986 Oct 11;70(8):476-8.
Substantial advances in understanding the regulation of thyrotrophin (TSH) secretion have been made during the past decade. The hypothalamic tripeptide, thyrotrophin-releasing hormone, is the major stimulator of TSH secretion, and thyroid hormones exert the major inhibitory influences on TSH secretion. Other hypothalamic peptides, biogenic amines and steroid hormones modulate TSH secretion. Basal serum TSH measurement is mainly of value in diagnosing primary hypothyroidism, but because the lower limit of the normal range of TSH is not clearly defined, dynamic measurements of TSH secretion are used in preference to basal measurements in assessing other disorders of the hypothalamopituitary-thyroid axis.
在过去十年中，对促甲状腺激素（TSH）分泌调节的理解取得了重大进展。下丘脑三肽促甲状腺激素释放激素是TSH分泌的主要刺激物，而甲状腺激素对TSH分泌发挥主要抑制作用。其他下丘脑肽、生物胺和类固醇激素调节TSH分泌。基础血清TSH测量主要用于诊断原发性甲状腺功能减退症，但由于TSH正常范围的下限未明确界定，在评估下丘脑-垂体-甲状腺轴的其他疾病时，优先使用TSH分泌的动态测量而非基础测量。
