Geerdsen J P, Pedersen V M, Kjaergård H K
Surgery. 1986 Nov;100(5):811-4.
Small bowel cutaneous fistula appearing after laparotomy was treated with the tetradecapeptide somatostatin in six patients to reduce the volume and enzyme content of the intestinal secretion. Continuous intravenous infusion of somatostatin diminished output from the fistula in all cases. Spontaneous fistula closure occurred after 11 to 33 days of treatment in four patients. There were no complications such as sepsis, peritonitis, or wound or skin problems from the contact with intestinal secretion. The hospital stay ranged from 19 to 50 days and bowel function was restored to normal. These preliminary results indicated that somatostatin can promote healing of small bowel fistula by inhibiting intestinal secretions.
六例剖腹术后出现小肠皮肤瘘的患者接受了十四肽生长抑素治疗，以减少肠液分泌量及酶含量。持续静脉输注生长抑素使所有患者的瘘管排出量减少。四名患者在治疗11至33天后瘘管自行闭合。未出现诸如败血症、腹膜炎或因接触肠液而导致的伤口或皮肤问题等并发症。住院时间为19至50天，肠功能恢复正常。这些初步结果表明，生长抑素可通过抑制肠液分泌促进小肠瘘的愈合。
