Mosier H D
Acta Endocrinol Suppl (Copenh). 1986;279:1-7. doi: 10.1530/acta.0.112s001.
Catch-up (compensatory) growth following transient growth retardation due to illness or starvation has long been recognized in biology and in clinical medicine. This report summarizes work utilizing experimental models in rats in efforts to elucidate the control of catch-up growth. The results support the hypothesis that the catch-up growth mechanism includes a set-point or reference for body size appropriate for age and that the control resides in the central nervous system. Growth hormone (GH) secretion is increased during catch-up growth, although the results also show that increased GH secretion is not required for catch-up growth acceleration. Environmental light modulates the effect of catch-up growth on GH secretion. The mechanisms for sensing a deficit in body size and for stimulating catch-up growth acceleration remain unknown.
由于疾病或饥饿导致短暂生长迟缓后的追赶（代偿性）生长，在生物学和临床医学中早已为人所知。本报告总结了利用大鼠实验模型开展的研究工作，旨在阐明追赶生长的控制机制。结果支持以下假说：追赶生长机制包括一个适合年龄的身体大小设定点或参考值，且控制作用存在于中枢神经系统。在追赶生长期间，生长激素（GH）分泌增加，不过结果也表明，追赶生长加速并不需要GH分泌增加。环境光照可调节追赶生长对GH分泌的影响。感知身体大小不足以及刺激追赶生长加速的机制仍不明晰。
