Hermanussen M, Rol de Lama M A, Romero A P, Ruiz C A, Burmeister J, Tresguerres J A
Department of Physiology, Medical School, Univ. Complutense, Madrid, Spain.
Growth Regul. 1996 Dec;6(4):230-7.
Catch-up or compensatory growth is known as a physiological phenomenon. However, most studies of catch-up growth were based on measurements of body weight, whereas changes in longitudinal bone growth remained largely undescribed. The present study describes the dynamics of both weight and longitudinal bone growth using mikro-knemometry, during normal feeding, severe food restriction (starvation), and refeeding of 14 intact and 28 GH-deficient male rats. Starvation induced rapid weight loss (P < 0.001), and stunted leg growth (P < 0.001). Refeeding led to rapid catch-up in weight of up to 4 times above normal daily weight gain, both in intact and GH-deficient animals, whereas an equivalent compensation of lower leg growth remained undetectable. Intact and GH-deficient animals show a circaseptan spontaneous variation of growth velocity (mini growth spurts). During starvation, mini growth spurts disappear, and return to normal after refeeding with no evidence of catch-up. In GH-deficient animals, GH (1 IU/rat, administered twice daily s.c. at 10:00 hand 16:00 h) was capable of augmenting catch-up in weight and, to a lesser extent, in leg length increment.
追赶生长或代偿性生长是一种生理现象。然而，大多数追赶生长的研究都是基于体重测量，而纵向骨骼生长的变化在很大程度上仍未得到描述。本研究使用微骨测量法描述了14只完整雄性大鼠和28只生长激素缺乏雄性大鼠在正常进食、严重食物限制（饥饿）和再喂养期间体重和纵向骨骼生长的动态变化。饥饿导致体重迅速下降（P < 0.001），腿部生长发育迟缓（P < 0.001）。再喂养导致完整和生长激素缺乏动物的体重迅速追赶，达到正常日增重的4倍以上，而小腿生长的同等补偿仍未检测到。完整和生长激素缺乏的动物生长速度呈现出每七天一次的自发变化（微小生长突增）。在饥饿期间，微小生长突增消失，再喂养后恢复正常，没有追赶生长的迹象。在生长激素缺乏的动物中，生长激素（1 IU/只大鼠，每天上午10:00和下午16:00皮下注射两次）能够增强体重的追赶，在较小程度上也能增加腿部长度的增加。
