Weil Zachary M, Karelina Kate
Behavioral Neuroendocrinology Group, Department of Neuroscience, Center for Brain and Spinal Cord Repair, Ohio State University Wexner Medical CenterColumbus, OH, United States.
Front Behav Neurosci. 2017 Jul 20;11:135. doi: 10.3389/fnbeh.2017.00135. eCollection 2017.
Traumatic brain injuries are strongly related to alcohol intoxication as by some estimates half or more of all brain injuries involve at least one intoxicated individual. Additionally, there is mounting evidence that traumatic brain injuries can themselves serve as independent risk factors for the development of alcohol use disorders, particularly when injury occurs during juvenile or adolescent development. Here, we will review the epidemiological and experimental evidence for this phenomenon and discuss potential psychosocial mediators including attenuation of negative affect and impaired decision making as well as neurochemical mediators including disruption in the glutamatergic, GABAergic, and dopaminergic signaling pathways and increases in inflammation.
创伤性脑损伤与酒精中毒密切相关，据一些估计，所有脑损伤中至少一半或更多涉及至少一名醉酒者。此外，越来越多的证据表明，创伤性脑损伤本身可能是酒精使用障碍发展的独立危险因素，尤其是在青少年发育期间发生损伤时。在此，我们将回顾这一现象的流行病学和实验证据，并讨论潜在的心理社会调节因素，包括负面影响的减轻和决策受损，以及神经化学调节因素，包括谷氨酸能、γ-氨基丁酸能和多巴胺能信号通路的破坏和炎症增加。
