Weil Zachary M, Corrigan John D, Karelina Kate
Zachary M.Weil, Ph.D., is an assistant professor in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio. John D. Corrigan, Ph.D., is a professor in the Department of Physical Medicine and Rehabilitation, Ohio State University Wexner Medical Center, Columbus, Ohio. Kate Karelina, Ph.D., is a research scientist in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio.
Alcohol Res. 2018;39(2):171-180.
Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or modulate the course of, alcohol use disorder (AUD). Critically, alcohol use after TBI is a key predictor of rehabilitation outcomes, prognosis, and additional head injuries. This review provides a general overview of the bidirectional relationship between TBI and AUD and a discussion of potential neuropsychological and neurobiological mechanisms that might underlie the relationship.
酒精使用与创伤性脑损伤（TBI）存在着不可分割的双向联系。酒精中毒是TBI最强的预测因素之一，相当一部分TBI发生在醉酒者身上。一种反向关系也正在显现，即TBI可作为酒精使用障碍（AUD）的危险因素或调节其病程。至关重要的是，TBI后的酒精使用是康复结果、预后及额外头部损伤的关键预测因素。本综述概述了TBI与AUD之间的双向关系，并讨论了可能构成这种关系基础的潜在神经心理学和神经生物学机制。
