使用维库溴铵后发生支气管痉挛。

Bronchospasm following the use of vecuronium.

作者信息

O'Callaghan A C, Scadding G, Watkins J

出版信息

Anaesthesia. 1986 Sep;41(9):940-2. doi: 10.1111/j.1365-2044.1986.tb12921.x.

DOI:10.1111/j.1365-2044.1986.tb12921.x

Abstract

A case history is presented which records bronchospasm due to vecuronium. Immunological investigations, including basophil degranulation tests, indicated that the bronchospasm was not caused by direct histamine release and was not IgE mediated. It was of interest that intradermal testing gave a positive wheal response against neuromuscular agents other than those involved in the anaesthetic procedure under investigation. A positive reaction to vecuronium was only obtained when given in a high concentration and accords with the general belief that vecuronium has extremely low potential for histamine release.

摘要

本文报告了一例因维库溴铵导致支气管痉挛的病例。包括嗜碱性粒细胞脱颗粒试验在内的免疫学调查表明，支气管痉挛并非由直接组胺释放引起，也不是由IgE介导的。有趣的是，皮内试验对除正在研究的麻醉过程中使用的神经肌肉药物以外的其他神经肌肉药物产生了阳性风团反应。只有在高浓度使用时，维库溴铵才出现阳性反应，这与维库溴铵组胺释放潜力极低的普遍观点一致。