Rombaut N, Heykants J, Vanden Bussche G
Ann Allergy. 1986 Nov;57(5):321-4.
Astemizole is a potent H1-antagonist devoid of sedative effects, which was found at single oral daily doses to be very effective in the treatment of allergic rhinitis, allergic conjunctivitis, and urticaria. Its interaction potential on other drugs was studied in various ways. Studies on salivary antipyrine clearance, the 6-beta-hydrocortisol excretion, the elimination rate of ethanol and the indocyanine-green clearance are presented. No changes were observed. Astemizole also was given in combination with diazepam or alcohol. Psychomotor performance failed to show any effects. In none of these studies was there any evidence of interaction of astemizole on other drugs. This review summarizes the data available thus far.
阿司咪唑是一种强效H1拮抗剂，无镇静作用，每日单剂量口服时被发现对过敏性鼻炎、过敏性结膜炎和荨麻疹的治疗非常有效。已通过多种方式研究了其与其他药物的相互作用可能性。本文展示了关于唾液中安替比林清除率、6-β-氢化可的松排泄、乙醇消除率和吲哚菁绿清除率的研究。未观察到变化。阿司咪唑还与地西泮或酒精联合使用。精神运动表现未显示出任何影响。在这些研究中，均未发现阿司咪唑与其他药物相互作用的证据。本综述总结了迄今为止可得的数据。
