Bateman D N, Chapman P H, Rawlins M D
Br J Clin Pharmacol. 1983 Sep;16(3):241-4. doi: 10.1111/j.1365-2125.1983.tb02156.x.
The effects of acute and chronic (3 months) dosing with astemizole on indocyanine green kinetics have been investigated in normal volunteers and patients. A single dose of astemizole 40 mg produced significant reduction in indocyanine green clearance (P less than 0.02) and volume of distribution (P less than 0.02) when assessed at 48 h, but not at 24 h. In six volunteers who did not receive astemizole there was no significant change in indocyanine green kinetics over a 48 h period. In seven patients on chronic treatment with astemizole there was no significant change in indocyanine green kinetics when these were measured at 1 month and 3 months and compared to pre-treatment values. The change in indocyanine green clearance and volume of distribution following acute astemizole treatment did not correlate with H1-receptor antagonism. Change in indocyanine green clearance following acute drug administration may not be due to changes in liver blood flow and should therefore be interpreted with caution.
已在正常志愿者和患者中研究了阿司咪唑急性和慢性（3个月）给药对吲哚菁绿动力学的影响。单剂量40毫克阿司咪唑在48小时评估时可使吲哚菁绿清除率（P<0.02）和分布容积（P<0.02）显著降低，但在24小时时未出现此情况。在6名未接受阿司咪唑的志愿者中，吲哚菁绿动力学在48小时内无显著变化。在7名接受阿司咪唑慢性治疗的患者中，在1个月和3个月测量吲哚菁绿动力学并与治疗前值比较时，未发现显著变化。急性阿司咪唑治疗后吲哚菁绿清除率和分布容积的变化与H1受体拮抗作用无关。急性给药后吲哚菁绿清除率的变化可能并非由于肝血流量的改变，因此应谨慎解读。
