Hackenthal E
Ann Endocrinol (Paris). 1986;47(3):145-55.
Renin secretion from juxtaglomerular cells of the kidney is controlled by several effector systems, such as renal perfusion pressure, renal nerve activity, salt load to the distal tubule and various humoral agents. The reactive behaviour of juxtaglomerular cells to these mechanisms is homologous to that of vascular smooth muscle cells of the kidney, i.e. manoeuvres inducing vasoconstriction inhibit renin secretion, whereas those inducing vasorelaxation stimulate renin secretion. This homology is partly explained by the fact that juxtaglomerular cells are modified smooth muscle cells. Intracellularly, an increase of cytosolic calcium has been identified as an inhibitory signal, whereas the major stimulatory signal appears to be cAMP (and the decrease of calcium). How intracellular calcium and cAMP are linked to the process of renin secretion, remains obscure.
肾脏近球细胞的肾素分泌受多种效应系统控制，如肾灌注压、肾神经活动、远端小管的盐负荷以及各种体液因子。近球细胞对这些机制的反应行为与肾脏血管平滑肌细胞的反应行为相似，即诱导血管收缩的操作会抑制肾素分泌，而诱导血管舒张的操作则会刺激肾素分泌。这种相似性部分是由于近球细胞是经过修饰的平滑肌细胞这一事实。在细胞内，胞质钙的增加已被确定为一种抑制信号，而主要的刺激信号似乎是环磷酸腺苷（以及钙的减少）。细胞内钙和环磷酸腺苷如何与肾素分泌过程相联系，目前仍不清楚。
