Ramos Kathleen J, Somayaji Ranjani, Nichols David P, Goss Christopher H
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Calgary, Calgary, AB, Canada.
Paediatr Drugs. 2018 Feb;20(1):1-7. doi: 10.1007/s40272-017-0256-y.
Comparative effectiveness research (CER) has become increasing central to clinical research in medicine. CER seeks to conduct clinical trials that compare different commonly used interventions in real-world settings (pragmatic clinical trials) and use a multitude of sources of evidence (including registries and cohort studies) to inform clinical decision making. CER also ensures that stakeholders (patients, families, care providers, insurers) have a voice in the research process by integrating formal stakeholder engagement as part of the research. This innovative approach to clinical research has distinct benefits and pitfalls. This review first defines what CER is and then describes some of its benefits and then pitfalls. The focus is on the role of CER in pediatrics.
比较效果研究（CER）在医学临床研究中已变得越来越核心。CER旨在开展临床试验，比较现实环境中不同的常用干预措施（实用临床试验），并利用多种证据来源（包括登记处和队列研究）为临床决策提供依据。CER还通过将正式的利益相关者参与纳入研究过程，确保利益相关者（患者、家庭、护理提供者、保险公司）在研究过程中有发言权。这种创新的临床研究方法有明显的益处和缺陷。本综述首先定义了什么是CER，然后描述了它的一些益处，接着是缺陷。重点是CER在儿科中的作用。
