Chandrashekara S, Shobha V, Dharmanand B G, Jois R, Kumar S, Mahendranath K M, Haridas V, Prasad S, Singh Y, Daware M A, Swamy A, Subramanian R, Somashekar S A, Shanthappa A M, Anupama K R
ChanRe Rheumatology and Immunology Center, Bangalore.
Reumatismo. 2017 Aug 3;69(2):47-58. doi: 10.4081/reumatismo.2017.898.
The aim was to study the prevalence of comorbidities in rheumatoid arthritis (RA) patients in everyday clinical practice and their association with disease-specific and demographic factors. The multi-center study recruited 3,247 (at 14 centers, and 265) were excluded due to incomplete data. The number of subjects considered for the analysis was 2982. The mean (±standard deviation) age was 48.98±12.64 years and the male-to-female ratio was 1:5. The data was collected based on a pre-structured pro forma by trained clinical research associates through interview and verification of charts and reports available in the patient records. The following comorbidities were studied: cardiovascular disease, hypertension, diabetes mellitus, hypercholesterolemia, thyroid disease, psychiatric diseases like depression, and pulmonary disease. Hypertension (20.7%), diabetes mellitus (14.4%) and thyroid disease (18.3%) were the most prevalent comorbidities. Hypercholesterolemia (5.3%), pulmonary diseases (2.1%), cardiovascular diseases (0.2%) and depression (0.03%) were prevalent in ≤5% of the study population. The overall presence of comorbidity increased with age and reduced with the duration of illness prior (DOIP). The age, gender, and DOIP differed significantly between groups with and without hypercholesterolemia. Females had a statistically increased prevalence of thyroid disease. The prevalence of comorbidities in RA patients from south India is around 40% and the incidence of comorbidity increased with age. As per the literature evidence, the prevalence in the current study subjects was higher when compared to prevalence of similar diseases occurring in the general south Indian population.
目的是研究日常临床实践中类风湿关节炎（RA）患者合并症的患病率及其与疾病特异性因素和人口统计学因素的关联。这项多中心研究招募了3247名患者（在14个中心），其中265名因数据不完整而被排除。纳入分析的受试者数量为2982名。平均（±标准差）年龄为48.98±12.64岁，男女比例为1:5。数据由经过培训的临床研究助理根据预先构建的表格，通过访谈以及核查患者记录中的图表和报告来收集。研究了以下合并症：心血管疾病、高血压、糖尿病、高胆固醇血症、甲状腺疾病、抑郁症等精神疾病以及肺部疾病。高血压（20.7%）、糖尿病（14.4%）和甲状腺疾病（18.3%）是最常见的合并症。高胆固醇血症（5.3%）、肺部疾病（2.1%）、心血管疾病（0.2%）和抑郁症（0.03%）在≤5%的研究人群中较为常见。合并症的总体患病率随年龄增加而升高，随患病时间（DOIP）缩短而降低。有高胆固醇血症和无高胆固醇血症的组在年龄、性别和DOIP方面存在显著差异。女性甲状腺疾病的患病率在统计学上有所增加。印度南部RA患者的合并症患病率约为40%，且合并症的发生率随年龄增加而升高。根据文献证据，与印度南部普通人群中类似疾病的患病率相比，本研究受试者中的患病率更高。
