基于日本健康保险数据库的一项横断面研究显示，类风湿关节炎患者心血管合并症的患病率较高。

High prevalence of cardiovascular comorbidities in patients with rheumatoid arthritis from a population-based cross-sectional study of a Japanese health insurance database.

机构信息

a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .

b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .

出版信息

Mod Rheumatol. 2016 Jul;26(4):522-8. doi: 10.3109/14397595.2015.1106682. Epub 2015 Dec 14.

DOI:10.3109/14397595.2015.1106682

PMID:26666766

Abstract

OBJECTIVE

To reveal any association between rheumatoid arthritis (RA) and cardiovascular comorbidities using a Japanese health insurance database.

METHOD

This population-based cross-sectional study was conducted using health insurance data provided by the Japan Medical Data Center Co., Ltd. We identified 2762 RA subjects having RA diagnostic codes (ICD10 codes; M05, M060, M062-63, M068-069) with at least two physician visits more than two months apart between June 2011 and May 2012 (RA group, n = 2762). We selected age- (±5 years), sex-, and study period-matched non-RA subjects (non-RA group, n = 27,620). We compared the prevalence of cardiovascular and related comorbidities (ischemic heart diseases [IHD], cerebral infarction, hypertension [HT], dyslipidemia [DL], and diabetes mellitus [DM]) between these groups and investigated the association between RA and cardiovascular comorbidities using a conditional logistic regression analysis.

RESULTS

The prevalence of all the investigated comorbidities in the RA group was significantly higher compared to the non-RA group. Odds ratios [95% confidence interval] of RA for IHD and cerebral infarction were 2.0 [1.5-2.5] and 3.1 [2.2-4.2] respectively, after adjusting for HT, DL, and DM.

CONCLUSIONS

This study revealed for the first time in the Japanese population that RA was significantly associated with cardiovascular comorbidities.

摘要

目的

利用日本健康保险数据库揭示类风湿关节炎（RA）与心血管合并症之间的任何关联。

方法

本基于人群的横断面研究使用日本医疗数据中心有限公司提供的健康保险数据进行。我们确定了 2762 名 RA 患者，这些患者在 2011 年 6 月至 2012 年 5 月期间至少有两次相隔两个月以上的 RA 诊断代码（ICD10 代码；M05、M060、M062-63、M068-069）的就诊记录（RA 组，n=2762）。我们选择了年龄（±5 岁）、性别和研究期间相匹配的非 RA 患者（非 RA 组，n=27620）。我们比较了两组患者心血管及相关合并症（缺血性心脏病[IHD]、脑梗死、高血压[HT]、血脂异常[DL]和糖尿病[DM]）的患病率，并使用条件逻辑回归分析调查 RA 与心血管合并症之间的关联。