儿茶酚胺（CCA）对线粒体代谢的影响，CCA是神经母细胞瘤分化的诱导剂之一。
Effects on mitochondrial metabolism of CCA, one inducer of neuroblastoma differentiation.
作者信息
Vayssiere J L, Larcher J C, Berthelot F, Benlot C, Gros F, Croizat B
出版信息
Biochem Biophys Res Commun. 1986 Nov 14;140(3):789-96. doi: 10.1016/0006-291x(86)90703-5.
PMID:2877666
Abstract
CCA, a potent neuroblastoma differentiation inducer, was shown by oxygraphic measurements to reduce significantly the O2 consumption of whole neuroblastoma cells as of mitochondria purified from neuroblastoma or mouse cortex. The effect of CCA on the respiration was compared to those of oligomycin. Our results suggest that the molecular target of CCA is the matrix F1 catalytic component of the F0F1 mitochondrial ATPase.
摘要
CCA是一种有效的神经母细胞瘤分化诱导剂，通过氧电极测量表明，它能显著降低整个神经母细胞瘤细胞以及从神经母细胞瘤或小鼠皮层纯化的线粒体的氧气消耗。将CCA对呼吸作用的影响与寡霉素的影响进行了比较。我们的结果表明，CCA的分子靶点是F0F1线粒体ATP酶的基质F1催化成分。
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