α-肾上腺素能受体激动剂和拮抗剂对哇巴因诱导的豚鼠心律失常和心脏骤停的影响。
Effects of alpha-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig.
作者信息
Thomas G P, Tripathi R M
出版信息
Br J Pharmacol. 1986 Oct;89(2):385-8. doi: 10.1111/j.1476-5381.1986.tb10271.x.
Abstract
Effects of alpha-adrenoceptor agonists and antagonists with different affinity for alpha 1- and alpha 2-receptors on ouabain-induced arrhythmias in guinea-pigs were studied. Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea-pigs by the slow intravenous infusion of ouabain. Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. It is concluded that selective alpha 1-receptor stimulation and alpha 2-receptor blockade increases the cardiotoxic effects of ouabain and selective alpha 2-receptor stimulation and alpha 1-receptor blockade inhibits ouabain-induced arrhythmias and cardiac arrest in guinea-pigs.
摘要
研究了对α1和α2受体具有不同亲和力的α-肾上腺素能受体激动剂和拮抗剂对哇巴因诱导的豚鼠心律失常的影响。通过缓慢静脉输注哇巴因，在麻醉的豚鼠中诱发早期心律失常、心室颤动和心脏骤停。去氧肾上腺素和育亨宾显著增强了哇巴因的心脏毒性，而哌唑嗪和可乐定则显示出显著的抗心律失常作用，并延迟了心脏骤停。得出结论：选择性α1受体刺激和α2受体阻断会增加哇巴因的心脏毒性，而选择性α2受体刺激和α1受体阻断可抑制哇巴因诱导的豚鼠心律失常和心脏骤停。
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