某些非甾体抗炎药对哇巴因诱导的豚鼠心律失常的影响。
Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.
作者信息
Tripathi R M, Kaushal R
机构信息
Department of Pharmacology, IDPL Research Centre, Hyderabad, India.
出版信息
Br J Pharmacol. 1988 Apr;93(4):747-50. doi: 10.1111/j.1476-5381.1988.tb11458.x.
Abstract
- Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied. 2. Ventricular premature beats, ventricular fibrillation and cardiac arrest were induced in pentobarbitone-anaesthetized guinea-pigs by a slow intravenous infusion of ouabain. 3. Aspirin and indomethacin were found to accord a significant protection to the guinea-pigs against arrhythmias whereas ketoprofen was found to be ineffective. 4. It is concluded that the protective effect of aspirin and indomethacin may be due to inhibition of synthesis and release of thromboxane A2 from the myocardium.
摘要
- 研究了某些非甾体抗炎药对哇巴因诱导的豚鼠心律失常的影响。2. 通过缓慢静脉输注哇巴因，在戊巴比妥麻醉的豚鼠中诱发室性早搏、心室颤动和心脏骤停。3. 发现阿司匹林和吲哚美辛对豚鼠心律失常有显著保护作用，而酮洛芬则无效。4. 得出结论，阿司匹林和吲哚美辛的保护作用可能是由于抑制了心肌中血栓素A2的合成和释放。
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