从药用昆虫中华婪步甲中分离得到的五种具有抗氧化活性的新酚类化合物。
Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera.
作者信息
Xiao Huai, Yin Tian-Peng, Dong Jian-Wei, Wu Xiu-Mei, Luo Qing, Luo Jian-Rong, Cai Le, Ding Zhong-Tao
机构信息
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, China.
出版信息
Molecules. 2017 Aug 4;22(8):1301. doi: 10.3390/molecules22081301.
Five new phenolic compounds rynchopeterines A-E (-), in addition to thirteen known phenolics, were isolated from Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A-E (-) exhibited significant antioxidant activities with IC values of 7.67-12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B () and C () showed mild cytotoxicity against tumor cell Caco-2 and A549.
除了13种已知的酚类化合物外，还从中国云南省彝族使用的药用昆虫“蜚蠊”中分离出5种新的酚类化合物——隐翅虫素A - E（-）。它们的结构是基于广泛的光谱分析（一维和二维核磁共振、高分辨质谱、红外光谱）以及计算电子圆二色性方法确定的。通过1,1 - 二苯基 - 2 - 苦基肼（DPPH）法测定，隐翅虫素A - E（-）表现出显著的抗氧化活性，IC值为7.67 - 12.3μg/mL。此外，隐翅虫素B（）和C（）对肿瘤细胞Caco - 2和A549显示出轻微的细胞毒性。
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