通过 C-C 和 C-N 键的串联形成还原 CO 固定：螺吲哚吡咯烷的合成。
Reductive CO Fixation via Tandem C-C and C-N Bond Formation: Synthesis of Spiro-indolepyrrolidines.
机构信息
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences , Lanzhou 730000, P. R. China.
出版信息
Org Lett. 2017 Aug 18;19(16):4259-4262. doi: 10.1021/acs.orglett.7b01906. Epub 2017 Aug 4.
We describe herein a tandem C-C and C-N bond-forming reaction in the reductive functionalization of CO, an abundant and cheap C1 chemical feedstock. This catalytic metal-free CO fixation afforded spiro-indolepyrrolidines by dearomatization of tryptamine derivatives with broad scope and good functional group tolerance under mild conditions.
我们在此描述了 CO 还原功能化中 C-C 和 C-N 键形成的串联反应，CO 是一种丰富且廉价的 C1 化学原料。在温和条件下，这种无金属催化的 CO 固定反应通过色胺衍生物的去芳构化作用，以广泛的范围和良好的官能团耐受性提供了螺吲哚吡咯烷。
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