State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP) , Chinese Academy of Sciences , Lanzhou 730000 , China.
Org Lett. 2018 Jun 1;20(11):3282-3285. doi: 10.1021/acs.orglett.8b01155. Epub 2018 May 15.
A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO fixation afforded β-unsubstituted acrylates and vinyl ketones in good yields with broad scope and good functional group tolerance under mild reaction conditions. Cost-effective and easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal was proved to be the key intermediate in this reductive functionalization of CO.
本文描述了一种新型的过渡金属免费还原脱氧磷叶立德与 CO 的烯烃化反应，CO 是一种丰富且可持续的 C1 化学原料。在温和的反应条件下，这种催化 CO 固定反应能够以良好的收率和广泛的适用性以及良好的官能团容忍性得到β-无取代的丙烯酸盐和乙烯基酮。经济高效且易于处理的聚甲基氢硅氧烷被用作还原剂。双（硅基）缩醛被证明是 CO 这种还原官能化反应的关键中间体。
