Minamimoto Ryogo, Xu Guofan, Jamali Mehran, Holley Dawn, Barkhodari Amir, Zaharchuk Greg, Iagaru Andrei
1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, 300 Pasteur Dr, Rm H-2200, Stanford University, Stanford, CA 94305-5281.
2 Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA.
AJR Am J Roentgenol. 2017 Nov;209(5):1136-1142. doi: 10.2214/AJR.17.18044. Epub 2017 Aug 4.
Differences in the attenuation correction methods used in PET/CT scanners versus the newly introduced whole-body simultaneous PET/MRI reportedly result in differences in standardized uptake values (SUVs) in the normal skeleton. The aim of the study was to compare the semiquantitative FDG uptake in the normal skeleton using time-of-flight (TOF) PET/MRI versus PET/CT with and without TOF.
Participants received a single FDG injection and underwent non-TOF and TOF PET/CT (n = 23) or non-TOF PET/CT and TOF PET/MRI (n = 50). Mean SUV (SUV) and maximum SUV (SUV) were measured from all PET scans for nine normal regions of the skeleton. Pearson correlation coefficients (r) were used to evaluate the SUV and SUV of normal skeleton between non-TOF and TOF PET/CT, as well as between non-TOF PET/CT and TOF PET/MRI. In addition, percentage differences in SUV and SUV of the normal skeleton between non-TOF and TOF PET/CT and between non-TOF PET/CT and TOF PET/MRI were evaluated.
The SUV and SUV in the normal skeleton significantly increased between non-TOF and TOF PET/CT, but they significantly decreased between non-TOF PET/CT and TOF PET/MRI. The SUV and SUV in normal skeleton showed good correlation between non-TOF PET/CT and TOF PET/MRI (SUV, r = 0.88; SUV, r = 0.91) and showed a similar trend between non-TOF and TOF PET/CT (SUV, r = 0.88; SUV, r = 0.94).
In the normal skeleton, SUV and SUV showed high correlations between PET/MRI and PET/CT. The MRI attenuation correction used in TOF PET/MRI provides reliable semiquantitative measurements in the normal skeleton.
据报道，PET/CT扫描仪中使用的衰减校正方法与新推出的全身同步PET/MRI中使用的衰减校正方法不同，这导致正常骨骼的标准化摄取值（SUV）存在差异。本研究的目的是比较使用飞行时间（TOF）PET/MRI与有或无TOF的PET/CT时，正常骨骼中的半定量FDG摄取情况。
参与者接受一次FDG注射，并接受非TOF和TOF PET/CT检查（n = 23）或非TOF PET/CT和TOF PET/MRI检查（n = 50）。从所有PET扫描中测量九个正常骨骼区域的平均SUV（SUV）和最大SUV（SUV）。使用Pearson相关系数（r）评估非TOF和TOF PET/CT之间以及非TOF PET/CT和TOF PET/MRI之间正常骨骼的SUV和SUV。此外，还评估了非TOF和TOF PET/CT之间以及非TOF PET/CT和TOF PET/MRI之间正常骨骼的SUV和SUV的百分比差异。
非TOF和TOF PET/CT之间，正常骨骼中的SUV和SUV显著增加，但在非TOF PET/CT和TOF PET/MRI之间显著降低。正常骨骼中的SUV和SUV在非TOF PET/CT和TOF PET/MRI之间显示出良好的相关性（SUV，r = 0.88；SUV，r = 0.91），并且在非TOF和TOF PET/CT之间显示出相似的趋势（SUV，r = 0.88；SUV，r = 0.94）。
在正常骨骼中，SUV和SUV在PET/MRI和PET/CT之间显示出高度相关性。TOF PET/MRI中使用的MRI衰减校正为正常骨骼提供了可靠的半定量测量。
