Lyons Karen, Seghers Victor, Sorensen James I L, Zhang Wei, Paldino Michael J, Krishnamurthy Rajesh, Rohren Eric M
1 Department of Radiology, Texas Children's Hospital, 6701 Fannin St, Ste 470, Houston, TX 77030.
2 Department of Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
AJR Am J Roentgenol. 2015 Nov;205(5):1094-101. doi: 10.2214/AJR.15.14304.
The purpose of this study was to compare standardized uptake values (SUVs) of normal tissues using MR attenuation-corrected versus CT attenuation-corrected (18)F-FDG PET in a pediatric population.
Thirty-five patients (21 boys; mean age, 13.3 years) referred for 47 PET/CT scans were recruited to undergo PET/MRI. MR attenuation correction was performed using an automated three-segment model. ROIs were drawn over nine normal structures to estimate SUV(min), SUV(mean), and SUV(max). Pearson rank correlation coefficients were calculated to compare SUVs obtained from MR and CT attenuation correction. In nine patients who underwent multiple PET/MRI studies, coefficients of variance and intraclass correlation coefficients were calculated to evaluate intrapatient SUV(max) variation.
Mean (± SD) time to imaging after FDG injection was 108 ± 17 minutes for PET/CT and 61 ± 6 minutes for PET/MRI. PET/MRI SUVs in all tissues were lower than those for PET/CT (mean difference, -28.9% ± 31.1%; p < 0.05). Very high or high correlation between PET/MRI and PET/CT SUV(max) was found in brain (r = 0.72), myocardium (r = 0.95), and bone marrow (r = 0.85) (p < 0.001). Moderate correlation was found in liver (r = 0.54), fat (r = 0.41), mean blood pool (r = 0.40), and psoas muscle (r = 0.38) (p < 0.01). Weak correlation was found in lung (r = 0.12) and iliacus muscle (r = 0.12). Compared with PET/CT, PET/MRI systematically undermeasured SUV. In nine patients who underwent multiple PET/MRI examinations, moderate or strong agreement was found in the SUV(max) of six of nine tissues, similar to the corresponding PET/CT examinations.
Our study showed overall high correlation for SUV measurements obtained from MR attenuation correction compared with CT attenuation correction, although PET/MRI underestimated SUV compared with PET/CT. SUVs measured from PET/MRI indicated good intrapatient reliability.
本研究旨在比较在儿科人群中使用磁共振衰减校正与计算机断层扫描（CT）衰减校正的氟代脱氧葡萄糖（18F-FDG）正电子发射断层显像（PET）所测得的正常组织标准化摄取值（SUV）。
招募35例患者（21例男孩；平均年龄13.3岁），他们因47次PET/CT扫描前来就诊，接受PET/MRI检查。使用自动三段模型进行磁共振衰减校正。在九个正常结构上绘制感兴趣区（ROI），以估计SUV（最小值）、SUV（平均值）和SUV（最大值）。计算Pearson等级相关系数，以比较磁共振和CT衰减校正所获得的SUV。在九例接受多次PET/MRI研究的患者中，计算方差系数和组内相关系数，以评估患者内SUV（最大值）的变化。
FDG注射后至PET/CT成像的平均（±标准差）时间为108±17分钟，PET/MRI为61±6分钟。PET/MRI在所有组织中的SUV均低于PET/CT（平均差异为-28.9%±31.1%；p<0.05）。在脑（r = 0.72）、心肌（r = 0.95）和骨髓（r = 0.85）中，PET/MRI与PET/CT的SUV（最大值）之间存在非常高或高的相关性（p<0.001）。在肝脏（r = 0.54）、脂肪（r = 0.41）、平均血池（r = 0.40）和腰大肌（r = 0.38）中存在中度相关性（p<0.01）。在肺（r = 0.12）和髂肌（r = 0.12）中存在弱相关性。与PET/CT相比，PET/MRI系统性地低估了SUV。在九例接受多次PET/MRI检查的患者中，九个组织中的六个组织的SUV（最大值）显示出中度或强一致性，与相应的PET/CT检查相似。
我们的研究表明，与CT衰减校正相比，磁共振衰减校正所获得的SUV测量值总体具有高度相关性，尽管PET/MRI与PET/CT相比低估了SUV。PET/MRI测量的SUV显示出良好的患者内可靠性。
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