咖啡因和麻黄碱刺激了洛杉矶肥胖大鼠的产热作用。

Caffeine and ephedrine stimulated thermogenesis in LA-corpulent rats.

作者信息

Tulp O L, Buck C L

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;85(1):17-9. doi: 10.1016/0742-8413(86)90045-9.

Abstract

Resting metabolic rate (RMR), as well as caffeine (CAF) and ephedrine (EPH) stimulated thermogenesis (VO2) were measured in young adult corpulent (corp) LA/N-cp (LA-corpulent) rats. RMR of lean was greater than corp. Administration of EPH, CAF and EPH + CAF resulted in 32, 48 and 50% increases in VO2, respectively, in both lean and corp rats. The time to attain maximal VO2 was similar for both drugs in both phenotypes, but the duration of maximal VO2 averaged 50, 26 and 42% longer in corp than lean for EPH, CAF and EPH + CAF, respectively. Acute weight loss following these treatments was greater for corp than lean, and corresponded with the duration of elevated VO2. These results are consistent with a normally functioning end-organ sympathomimetic receptor system in the corp phenotype of the LA/N-cp rat, and suggest that obesity in this model may be caused by factors other than defective brown fat thermogenesis at the end organ level.

摘要

在年轻成年肥胖的LA/N-cp（LA-肥胖）大鼠中测量了静息代谢率（RMR）以及咖啡因（CAF）和麻黄碱（EPH）刺激的产热（VO2）。瘦大鼠的RMR高于肥胖大鼠。给予EPH、CAF和EPH + CAF后，瘦大鼠和肥胖大鼠的VO2分别增加了32%、48%和50%。两种表型的大鼠中，两种药物达到最大VO2的时间相似，但对于EPH、CAF和EPH + CAF，肥胖大鼠最大VO2的持续时间分别比瘦大鼠平均长50%、26%和42%。这些处理后肥胖大鼠的急性体重减轻比瘦大鼠更大，且与VO2升高的持续时间相关。这些结果与LA/N-cp大鼠肥胖表型中终末器官拟交感神经受体系统功能正常一致，并表明该模型中的肥胖可能由终末器官水平棕色脂肪产热缺陷以外的因素引起。