Tulp O L
Life Sci. 1984 Oct 15;35(16):1699-704. doi: 10.1016/0024-3205(84)90182-6.
The capacity for non-shivering thermogenesis was measured in groups of 12 week-old congenic lean and corpulent LA/N-cp rats of both sexes to determine if their obese state might be associated with an impairment in energy expenditure via non-shivering thermogenesis. Body weights of the corpulent phenotypes were 1.6 to 1.8 times greater than those of the lean phenotype. Measurements of resting oxygen consumption were similar in lean and in corpulent rats, and were greater in female than in male rats. Isoproterenol stimulation resulted in a significant increase in oxygen consumption in lean rats, while the rates of oxygen consumption of isoproterenol-stimulated corpulent rats were unchanged. Acute exposure of male rats to a 5 degrees C cold environment resulted in significant decreases in colonic and in rectal temperature in both phenotypes, but body temperatures recovered more rapidly in lean than in corpulent rats. Urinary VMA excretion was greater in lean than in corpulent rats and increased following cafeteria-feeding in lean but not in corpulent rats. These observations are consistent with an impaired mechanism of sympathetically-mediated thermogenesis in the corpulent phenotype of the LA/N-cp rat, and which may be a contributing factor in the development of their obese state via a decreased capacity for energy expenditure.
为了确定12周龄同基因瘦型和肥胖型LA/N-cp大鼠的肥胖状态是否可能与非颤抖性产热导致的能量消耗受损有关，对两组不同性别的大鼠进行了非颤抖性产热能力的测量。肥胖表型大鼠的体重比瘦型表型大鼠重1.6至1.8倍。瘦型和肥胖型大鼠的静息氧耗测量值相似，且雌性大鼠的静息氧耗高于雄性大鼠。异丙肾上腺素刺激使瘦型大鼠的氧耗显著增加，而异丙肾上腺素刺激的肥胖型大鼠的氧耗率没有变化。雄性大鼠急性暴露于5摄氏度的寒冷环境中，两种表型大鼠的结肠和直肠温度均显著下降，但瘦型大鼠的体温恢复速度比肥胖型大鼠更快。瘦型大鼠的尿香草扁桃酸（VMA）排泄量高于肥胖型大鼠，瘦型大鼠在自助餐喂养后VMA排泄量增加，而肥胖型大鼠则没有。这些观察结果与LA/N-cp大鼠肥胖表型中交感神经介导的产热机制受损一致，这可能是通过降低能量消耗能力导致其肥胖状态发展的一个促成因素。
