间质干细胞在纤维性疾病中的作用。
Mesenchymal Stem Cells in Fibrotic Disease.
机构信息
Institute of Life Sciences, Wenzhou University, Wenzhou University-Wenzhou Medical University Collaborative Innovation Center of Biomedicine, Wenzhou, Zhejiang, China; Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany.
Division of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, RWTH Aachen University, Aachen, Germany.
出版信息
Cell Stem Cell. 2017 Aug 3;21(2):166-177. doi: 10.1016/j.stem.2017.07.011.
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.
纤维化与器官衰竭和高死亡率相关，通常表现为肌成纤维细胞的异常积聚。因此，研究各种疾病中肌成纤维细胞的细胞起源是开发靶向抗纤维化治疗的一种有前途的策略。最近使用遗传谱系追踪技术的研究表明，在纤维化发展过程中，多种器官驻留的血管周间充质干细胞（MSC）样细胞和骨髓间充质干细胞参与了肌成纤维细胞的生成。在这篇综述中，我们概述了 MSC 和 MSC 样细胞在肾脏、肺、心脏、肝脏、皮肤和骨髓中肌成纤维细胞介导的纤维性病中的新作用。
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