Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Environ Toxicol Pharmacol. 2017 Sep;54:191-198. doi: 10.1016/j.etap.2017.07.011. Epub 2017 Jul 22.
Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35days. Compared to controls, glucose disappearance rates were lower (p=0.035) 15-120min after glucose gavage, and blood glucose concentrations were lower (p=0.038) 30min after insulin injection in overload lithium broilers. Overload lithium decreased (p<0.05) glycogen and glucose-6-phosphate concentrations in liver, but increased (p<0.05) their concentrations in pectoralis major. Overload lithium increased (p<0.05) mRNA expression of glucose transporter (GLUT) 3 and GLUT9 in liver, and GLUT1, GLUT3, GLUT8, and GLUT9 in pectoralis major, but decreased (p<0.05) cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in liver and mitochondrial PEPCK in pectoralis major. These results suggest that dietary overload lithium decreases glucose tolerance and gluconeogenesis, but increases insulin sensitivity and glucose transport in broiler chickens.
锂，如同胰岛素一样，可激活肝醣合成酶并刺激大鼠脂肪细胞中的葡萄糖转运。为了研究饮食中超载锂对肉鸡葡萄糖代谢的影响，我们将 1 日龄小鸡喂食基础饲料，其中添加 0（对照）或 100mg 锂/公斤（过载锂），共 35 天。相较于对照组，过载锂组小鸡在灌胃葡萄糖后 15-120 分钟时葡萄糖清除率更低（p=0.035），在注射胰岛素后 30 分钟时血糖浓度更低（p=0.038）。过载锂降低了肝脏中肝醣和葡萄糖-6-磷酸的浓度（p<0.05），但增加了胸肌中的浓度（p<0.05）。过载锂增加了肝脏中葡萄糖转运蛋白（GLUT）3 和 GLUT9 的 mRNA 表达，以及胸肌中 GLUT1、GLUT3、GLUT8 和 GLUT9 的表达，但降低了肝脏中细胞质磷酸烯醇丙酮酸羧激酶（PEPCK）和胸肌中线粒体 PEPCK 的表达（p<0.05）。这些结果表明，饮食中超载锂降低了肉鸡的葡萄糖耐量和糖异生能力，但提高了其胰岛素敏感性和葡萄糖转运能力。
