特发性嗜睡症
Idiopathic Hypersomnia.
作者信息
Trotti Lynn Marie
机构信息
Department of Neurology, Emory Sleep Center, Emory University School of Medicine, 12 Executive Park Drive Northeast, Atlanta, GA 30329, USA.
出版信息
Sleep Med Clin. 2017 Sep;12(3):331-344. doi: 10.1016/j.jsmc.2017.03.009. Epub 2017 Jun 16.
Abstract
Idiopathic hypersomnia (IH) is a chronic neurologic disorder of daytime sleepiness, accompanied by long sleep times, unrefreshing sleep, difficulty in awakening, cognitive dysfunction, and autonomic symptoms. The cause is unknown; a genetic predisposition is suggested. Autonomic, inflammatory, or immune dysfunction has been proposed. Diagnosis involves a clinical history and objective testing. There are no approved treatments for IH, but modafinil is typically considered first-line. A substantial fraction of patients with IH are refractory or intolerant to standard treatments, and different treatment strategies using novel therapeutics are necessary. Even with current treatment options, quality of life and safety may remain impaired.
摘要
特发性嗜睡症（IH）是一种导致日间嗜睡的慢性神经系统疾病，伴有睡眠时间长、睡眠后无恢复感、觉醒困难、认知功能障碍和自主神经症状。病因不明；提示有遗传易感性。有人提出存在自主神经、炎症或免疫功能障碍。诊断包括临床病史和客观检查。目前尚无获批用于治疗IH的方法，但莫达非尼通常被视为一线治疗药物。相当一部分IH患者对标准治疗无效或不耐受，因此需要采用新型疗法的不同治疗策略。即使采用目前的治疗方案，生活质量和安全性可能仍会受到损害。
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