溶血磷脂酰胆碱通过涉及两种炎性小体的新途径激活小胶质细胞中的半胱天冬酶-1。
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes.
作者信息
Scholz Holger, Eder Claudia
机构信息
Charité - Universitätsmedizin Berlin, Institute of Physiology, 10117 Berlin, Germany.
Charité - Universitätsmedizin Berlin, Institute of Physiology, 10117 Berlin, Germany.
出版信息
J Neuroimmunol. 2017 Sep 15;310:107-110. doi: 10.1016/j.jneuroim.2017.07.004. Epub 2017 Jul 10.
Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with lysophosphatidylcholine (LPC), a proinflammatory lipid generated under pathological conditions in the brain. LPC-induced caspase-1 activation in microglia was found to depend on LPS prestimulation, inflammasome NLRP3 and adaptor molecule ASC. Furthermore, knockdown of inflammasome NLRC4 inhibited LPC-stimulated caspase-1 activity in microglia, suggesting the requirement of two inflammasomes for optimal caspase-1 activity.
炎性小体在脑病理学中调节小胶质细胞半胱天冬酶-1的激活及随后的神经炎症过程。在本研究中，我们鉴定出在用溶血磷脂酰胆碱（LPC）刺激小胶质细胞后可导致半胱天冬酶-1激活的炎性小体，LPC是大脑病理条件下产生的一种促炎脂质。发现LPC诱导的小胶质细胞半胱天冬酶-1激活依赖于脂多糖预刺激、炎性小体NLRP3和接头分子ASC。此外，炎性小体NLRC4的敲低抑制了LPC刺激的小胶质细胞半胱天冬酶-1活性，提示需要两种炎性小体来实现最佳的半胱天冬酶-1活性。
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