19号染色体上七个限制性片段长度多态性（RFLP）与强直性肌营养不良的区域定位及连锁关系
Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.
作者信息
Shaw D J, Meredith A L, Sarfarazi M, Harley H G, Huson S M, Brook J D, Bufton L, Litt M, Mohandas T, Harper P S
出版信息
Hum Genet. 1986 Nov;74(3):262-6. doi: 10.1007/BF00282545.
PMID:2877933
Abstract
We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis for a linkage map of most of chromosome 19, and suggest that the myotonic dystrophy locus is close to the centromere.
摘要
我们研究了19号染色体上7种DNA多态性之间以及它们与强直性肌营养不良基因座之间的遗传连锁关系。利用体细胞杂种中的易位，将DNA序列定位到染色体的不同区域。这些结果为19号染色体大部分区域的连锁图谱提供了基础，并表明强直性肌营养不良基因座靠近着丝粒。
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