a Department of Ophthalmology, School of Medicine , Dicle University , Diyarbakir , Turkey.
b Department of Internal Medicine , Elazığ Training and Research Hospital , Elazığ , Turkey.
Arch Physiol Biochem. 2018 Feb;124(1):75-79. doi: 10.1080/13813455.2017.1361450. Epub 2017 Aug 5.
To compare the retina ganglion cell complex (GCC) layer and peripapillary nerve fibre layer thickness (pRNFL) in patients with prediabetes and healthy subjects analysed by spectral domain optical coherence tomography (SD-OCT).
This cross-sectional and comparative study included prediabetic patients and healthy subjects. All participants underwent SD-OCT measurement of pRNFL thickness, and GCC thickness.
A total of 30 eyes of the 30 patients with prediabetes and 30 eyes of 30 controls were included. The overall calculated pRNFL thicknesses were similar between the prediabetic and control subjects. The GCC thickness was significantly lower in all quadrants of the inner macula, and outer nasal quadrant in the prediabetes group when compared to the control group.
Our study demonstrated that inner macular GCC thickness was significantly thinner in prediabetic subjects. As a result neurodegeneration may play role in the thinning of GCC.
通过谱域光相干断层扫描（SD-OCT）比较分析糖尿病前期患者和健康受试者的视网膜神经节细胞复合体（GCC）层和视盘周围神经纤维层（pRNFL）厚度。
本横断面对比研究纳入了糖尿病前期患者和健康受试者。所有参与者均接受 SD-OCT 测量 pRNFL 厚度和 GCC 厚度。
共纳入 30 例糖尿病前期患者的 30 只眼和 30 例对照者的 30 只眼。糖尿病前期组和对照组的整体计算 pRNFL 厚度相似。与对照组相比，糖尿病前期组所有内黄斑象限和外鼻象限的 GCC 厚度均显著降低。
本研究表明，糖尿病前期患者的内黄斑 GCC 厚度明显变薄。因此，神经退行性变可能在 GCC 变薄中起作用。
