Yu Xiao-Hua, Zhao Jing, Zhang Shu-Cheng, Li Jian-Hui, Zheng Jun-Biao, Li Zheng, Liang Guo-Qing, Shi Hui-Juan, Zhou Wei-Jin, Zhu Qian-Xi
a Department of Urology , The First People's Hospital of Jiashan , Jiaxing , Zhejiang , China.
b Department of Reproductive Epidemiology and Social Science, Key Laboratory of Reproduction Regulation of NPFPC , SIPPR, IRD, Fudan University , Shanghai , China.
Aging Male. 2017 Dec;20(4):235-240. doi: 10.1080/13685538.2017.1361399. Epub 2017 Aug 5.
To analyze the impact of age, BMI and sex hormone on aging males' symptoms (AMS) and the 5-item version of the international index of erectile function (IIEF-5) scores in middle-aged and elderly Chinese men.
A population-based cross-sectional study was conducted in Jiashan County. A total of 969 men, aged between 40 and 80 years old, were admitted. Physical examination and the sex hormones were measured, and AMS and IIEF-5 scores were assessed.
The oneway ANOVA analysis indicated older age groups had higher AMS total-scores, somatic and sexual sub-scores, and lower IIEF5 scores (all p < .01). Pairwise correlation (r) analyses showed the significant associations between AMS and age or sex hormone (cFT, Bio-T, SHBG, and LH) levels, and similar for IIEF5. However, when age was adjusted, the correlation coefficients (r) weakened, and correlation significance disappeared, except LH (for AMS: r = 0.096, p = .009; for IIEF-5: r = -0.140, p = .001). Multiple linear regressions confirmed the influence of increased age and LH on the AMS and IIEF5 scores.
CFT, Bio-T and SHBG failed to yield any additional predicting information when age was adjusted. To improve the male reproductive health, future research should pay more attention on aging-related comorbidities and how to improve general wellness.
分析年龄、体重指数（BMI）和性激素对中国中老年男性衰老男性症状（AMS）及国际勃起功能指数5项版本（IIEF-5）评分的影响。
在嘉善县进行一项基于人群的横断面研究。共纳入969名年龄在40至80岁之间的男性。进行体格检查并检测性激素，评估AMS及IIEF-5评分。
单因素方差分析表明，年龄较大组的AMS总分、躯体和性功能子评分较高，而IIEF-5评分较低（均P<0.01）。两两相关性（r）分析显示，AMS与年龄或性激素（游离睾酮、生物活性睾酮、性激素结合球蛋白和促黄体生成素）水平之间存在显著关联，IIEF-5情况类似。然而，调整年龄后，相关系数（r）减弱，相关性显著性消失，但促黄体生成素除外（对于AMS：r=0.096，P=0.009；对于IIEF-5：r=-0.140，P=0.001）。多元线性回归证实年龄增加和促黄体生成素对AMS及IIEF-5评分有影响。
调整年龄后，游离睾酮、生物活性睾酮和性激素结合球蛋白未能提供任何额外的预测信息。为改善男性生殖健康，未来研究应更多关注与衰老相关的合并症以及如何改善总体健康状况。
