Liang Guoqing, Song Yuxuan, Liu Li, Zhou Kechong, Tian Jia, Li Jianhui, Shi Huijuan, Zhu Qianxi, Wang Jun, Zheng Junbiao, Yu Xiaohua, Zhang Shucheng, Li Zheng, Liu Xiaoqiang
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.
Andrologia. 2021 Jun;53(5):e14013. doi: 10.1111/and.14013. Epub 2021 Feb 18.
The association between hypogonadism symptoms and the levels of serum hormones are still in debate. To investigate the relationship between hypogonadism symptoms and serum hormones in middle-aged and elderly Chinese men, this community-based cross-sectional study was conducted based on a total of 965 ageing men. The ageing males' symptom (AMS) scale, International Index of Erectile Function-5 (IIEF-5), International Prostate Symptom Score (IPSS) questionnaires and related variables were assessed. Blood tests for total testosterone (TT), sex hormone-binding globulin (SHBG) and luteinising hormone (LH) were performed. Serum level of free testosterone (FT) and bioavailable testosterone (Bio-T) was calculated. The mean age was 56.34 ± 8.85 years. Total AMS score was significantly associated with all five serum hormones (LH: p < 0.001; SHBG: p < 0.001; TT: p =.043; FT: p = 0.007; Bio-T: p < 0.001). We identified sexual and somatic symptoms were obviously related to five serum hormones, while psychological symptoms seemed to have no association with serum hormones. After adjusting for age and BMI, multiple linear regression analysis indicated that LH had positive correlations with total AMS score, somatic and sexual symptom score (p < 0.05). In conclusion, LH and SHBG had the strongest correlation hypogonadism and might be used as early predictors for symptomatic hypogonadism in the near future.
性腺功能减退症状与血清激素水平之间的关联仍存在争议。为了研究中国中老年男性性腺功能减退症状与血清激素之间的关系，本研究基于965名老年男性开展了一项社区横断面研究。对老年男性的症状（AMS）量表、国际勃起功能指数-5（IIEF-5）、国际前列腺症状评分（IPSS）问卷及相关变量进行了评估。检测了总睾酮（TT）、性激素结合球蛋白（SHBG）和黄体生成素（LH）的血液指标。计算了游离睾酮（FT）和生物可利用睾酮（Bio-T）的血清水平。平均年龄为56.34±8.85岁。总AMS评分与所有五种血清激素均显著相关（LH：p<0.001；SHBG：p<0.001；TT：p=0.043；FT：p=0.007；Bio-T：p<0.001）。我们发现性症状和躯体症状与五种血清激素明显相关，而心理症状似乎与血清激素无关。在调整年龄和BMI后，多元线性回归分析表明LH与总AMS评分、躯体和性症状评分呈正相关（p<0.05）。总之，LH和SHBG与性腺功能减退的相关性最强，在不久的将来可能用作症状性性腺功能减退的早期预测指标。
