Li Jian-Hui, Yu Xiao-Hua, Zheng Jun-Biao, Zhao Jing, Wang Jun, Shen Yu-Zhong, Li Yu-Min, Yu Jin-Feng, Li Dong, Xu Jia-Neng, Zhu Qian-Xi
a Department of Urology , The First People's Hospital of Jiashan , Zhejiang , PR China and.
b Department of Reproductive Epidemiology and Social Science , Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University , Shanghai , PR China.
Aging Male. 2016 Sep;19(3):143-147. doi: 10.1080/13685538.2016.1188068. Epub 2016 Jun 1.
The aim of this study was to analyze the age-related recession trajectory of reproductive health indices in middle-aged and elderly Chinese men.
A population-based cross-sectional study was conducted in Jiashan County, Zhejiang in 2012. Healthy men between 40 and 80 years of age were considered eligible for the study. Physical examination and the sex hormones were measured. The subjects were assessed based on the 5-item version of the International Index of Erectile Function (IIEF-5) for Erectile Dysfunction (ED), and Aging Males' Symptoms (AMS) scale for Symptomatic Late-Onset Hypogonadism (SLOH).
TG showed a decrease at age 60 years. Testis volume and TT did not show significant difference among the four age groups; cFT began to decrease at age 50 years and Bio-T decreased faster at age 50 years. SHBG and LH increased faster at age 50 and 70 years, respectively. IIEF5 score decrease faster at age 60 years. AMS scores increased faster at age 70 years. With the increase in age, the symptoms of ED and SLOH became severer.
Different indices on reproductive health of men showed turning points at different ages. At first, androgenic sex hormones decreased faster, and then erectile dysfunction got severer, and the last overall male syndromes declined.
本研究旨在分析中国中老年男性生殖健康指标与年龄相关的衰退轨迹。
2012年在浙江省嘉善县进行了一项基于人群的横断面研究。40至80岁的健康男性被认为符合研究条件。进行了体格检查并测量了性激素。根据国际勃起功能指数（IIEF-5）的5项版本评估勃起功能障碍（ED），并根据老年男性症状（AMS）量表评估症状性迟发性性腺功能减退（SLOH）。
甘油三酯（TG）在60岁时出现下降。睾丸体积和总睾酮（TT）在四个年龄组之间未显示出显著差异；计算游离睾酮（cFT）在50岁时开始下降，生物活性睾酮（Bio-T）在50岁时下降更快。性激素结合球蛋白（SHBG）和促黄体生成素（LH）分别在50岁和70岁时升高更快。IIEF5评分在60岁时下降更快。AMS评分在70岁时升高更快。随着年龄的增加，ED和SLOH的症状变得更严重。
男性生殖健康的不同指标在不同年龄出现转折点。首先，雄激素性激素下降更快，然后勃起功能障碍变得更严重，最后整体男性综合征下降。
