Expression and prognostic significance of and in liver cancer.

The purpose of this study was to investigate the expression of and in liver cancer, and examine the correlations with pathological parameters and prognosis. We collected tumors and tumor-adjacent normal tissue from 70 patients with liver cancer admitted to the Department of General Surgery of Zhejiang Hospital. The expression of by RT-qPCR was significantly lower in liver cancer tissues than that in the tumor-adjacent normal tissues, and the low expression was correlated with the lymphatic metastasis and TNM stage. By contrast, the expression of was significantly higher in liver cancer than that in the tumor-adjacent tissues, and the high expression was correlated with the lymphatic metastasis and TNM stage. The overall 5-year survival rate of patients was 12.9% (9/70). Single-factor survival analysis revealed that and were the factors affecting the overall survival rate of liver cancer (P<0.05) and multivariate survival analysis by Cox proportional hazards model showed that and were the independent factors affecting the survival time of patients with liver cancer. Low expression of and high expression of are closely correlated with the occurrence and development of liver cancer, especially lymphatic metastasis and TNM stage. Thus, and can serve as reference biomarkers for guiding the treatment of liver cancer and for estimating prognosis.