Wakiya Taiichi, Kudo Daisuke, Ishido Keinosuke, Kimura Norihisa, Yakoshi Yuta, Toyoki Yoshikazu, Kijima Hiroshi, Hakamada Kenichi
Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.
Mol Clin Oncol. 2017 Aug;7(2):200-204. doi: 10.3892/mco.2017.1314. Epub 2017 Jun 29.
With the prolongation of the mean lifespan, the number of elderly individuals undergoing liver resection for colorectal cancer liver metastasis (CRLM) following chemotherapy has increased. However, the effect of age on the development of chemotherapy-associated liver injury (CALI) in CRLM remains unclear. The aim of the present study was to elucidate the effect of age on the development of CALI in CRLM. A total of 64 patients undergoing liver resection for CRLM following oxaliplatin-based chemotherapy (OBC) were investigated. The patients were divided into three groups (group A: <65 years, group B: 65-74 years and group C: >75 years) according to age at surgery, and the development rate of CALI was compared between the groups. The patients underwent pathological assessments to determine the degree of histopathological injury of the non-cancerous liver parenchyma. Group A included 37 cases, group B 17 cases and group C 10 cases. There were no significant differences among the groups regarding the number of OBC cycles and duration of OBC cessation. Sinusoidal injury was observed in 27.0, 29.4 and 30.0% of the cases in groups A, B and C, respectively; the differences were not statistically significant (P=0.479). Steatohepatitis was observed in 35.1, 35.3 and 40.0% of the cases in groups A, B and C, respectively; the differences were not statistically significant (P=0.958). There was no significant correlation between age and sinusoidal pathological score (r=-0.102, P=0.423) or non-alcoholic fatty liver disease activity score (r≤0.001, P=0.997). Therefore, the development of CALI following OBC treatment in CRLM was not found to differ by age.
随着平均寿命的延长，化疗后因结直肠癌肝转移（CRLM）接受肝切除的老年患者数量有所增加。然而，年龄对CRLM中化疗相关肝损伤（CALI）发生的影响仍不清楚。本研究的目的是阐明年龄对CRLM中CALI发生的影响。共调查了64例接受基于奥沙利铂的化疗（OBC）后因CRLM进行肝切除的患者。根据手术时的年龄将患者分为三组（A组：<65岁，B组：65 - 74岁，C组：>75岁），并比较各组之间CALI的发生率。患者接受病理评估以确定非癌性肝实质的组织病理学损伤程度。A组37例，B组17例，C组10例。各组之间在OBC周期数和OBC停药持续时间方面无显著差异。A、B、C组分别有27.0%、29.4%和30.0%的病例观察到窦性损伤；差异无统计学意义（P = 0.479）。A、B、C组分别有35.1%、35.3%和40.0%的病例观察到脂肪性肝炎；差异无统计学意义（P = 0.958）。年龄与窦性病理评分（r = -0.102，P = 0.423）或非酒精性脂肪性肝病活动评分（r≤0.001，P = 0.997）之间无显著相关性。因此，未发现CRLM患者在OBC治疗后CALI的发生因年龄而异。
