School of Medicine, Cardiff University, Cardiff, Wales, UK.
Centre for Trial Research (CTR), Cardiff University, Cardiff, Wales, UK.
Pediatr Diabetes. 2018 May;19(3):566-573. doi: 10.1111/pedi.12565. Epub 2017 Aug 7.
Children with new onset type 1 diabetes (T1D) are at risk of developing the life-threatening condition ketoacidosis if they have a delayed diagnosis. The rate of children presenting in ketoacidosis remains high in a number of countries worldwide. To ensure interventions to raise awareness of symptoms are effective a systematic review was conducted to evaluate previous publicity campaigns.
A range of databases was searched using search terms relating to T1D, publicity campaigns, and symptom awareness. Identified articles were checked against the inclusion criteria, ensuring interventions were designed to target individuals prior to diagnosis of T1D. Papers were independently assessed under the criteria specified within the Critical Appraisal Skills Programme checklist.
The initial search retrieved 1537 papers and following screening 20 were identified for full consideration. Thirteen did not meet the inclusion criteria, leaving 7 to be assessed. Of these 7, 2 observational case-control studies reported a reduction in the rate of ketoacidosis following a publicity campaign using posters and providing glucose testing equipment to primary healthcare professionals. Four observational cohort studies, utilized posters, and media campaigns; 2 reported a reduction in the rate of ketoacidosis and 2 reported no difference following their interventions. A feasibility study, not designed to evaluate effectiveness, reported some anecdotal evidence of a more timely diagnosis.
Due to the methodological limitations of the studies identified, it is not possible to make a definitive conclusion on the effectiveness of the interventions reported.
儿童新诊断 1 型糖尿病(T1D)如果诊断延迟,有发生危及生命的酮症酸中毒的风险。在世界上许多国家,儿童出现酮症酸中毒的比例仍然很高。为了确保提高症状意识的干预措施有效,我们进行了系统评价,以评估先前的宣传活动。
使用与 T1D、宣传活动和症状意识相关的搜索词,在一系列数据库中进行了搜索。根据纳入标准检查确定的文章,确保干预措施旨在 T1D 诊断之前针对个人设计。根据关键评估技能计划清单中规定的标准,对论文进行独立评估。
最初的搜索检索到 1537 篇论文,经过筛选,有 20 篇被确定为全文考虑。其中 13 篇不符合纳入标准,因此有 7 篇被评估。在这 7 篇中,2 项观察性病例对照研究报告称,在使用海报和向初级保健专业人员提供葡萄糖检测设备进行宣传活动后,酮症酸中毒的发生率有所降低。4 项观察性队列研究利用海报和媒体宣传活动;其中 2 项报告酮症酸中毒发生率降低,2 项报告干预后无差异。一项旨在评估可行性而不是评估效果的研究报告了一些更及时诊断的轶事证据。
由于确定的研究存在方法学上的局限性,因此无法对报告的干预措施的有效性得出明确结论。