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土耳其儿童接种肺炎球菌结合疫苗后，健康幼儿鼻咽部肺炎球菌携带情况。

Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey.

机构信息

Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.

Department of Medical Microbiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.

出版信息

Balkan Med J. 2017 Aug 4;34(4):362-366. doi: 10.4274/balkanmedj.2016.1256.

DOI:10.4274/balkanmedj.2016.1256
PMID:28783024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5615970/
Abstract

AIMS

To determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine.

METHODS

This cross-sectional study was conducted on 150 healthy Turkish children between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated.

RESULTS

The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12.6%) children who received full-dose PCV13 vaccine. The highest carriage rate was observed among children younger than 24 months (76.2%). In multivariate analysis, respiratory infection in recent months, age, attendance at a day-care center and antibiotic usage were not statistically significant risk factors for carriage. Overall, S. pneumoniae strains were considered as penicillin susceptible and antimicrobial resistance was limited.

CONCLUSION

We observed a low rate of pneumococcal carriage in children after PCV13 implementation compared with that of children receiving PCV7. Although it was reduced, vaccine serotype colonization in PCV13-vaccinated children remains persistent.

摘要

目的

确定接种肺炎球菌结合疫苗的 0-6 岁健康儿童中肺炎链球菌鼻咽携带率。

方法

本横断面研究纳入了 150 名 1 个月至 6 岁的土耳其健康儿童。进行血清分型并评估携带的危险因素。

结果

总携带率为 14%。在接受了全剂量 13 价肺炎球菌结合疫苗（PCV13）的 17 名儿童（12.6%）中确定了疫苗型血清型。24 个月以下的儿童携带率最高（76.2%）。多变量分析显示，最近几个月的呼吸道感染、年龄、入托和使用抗生素不是携带的统计学显著危险因素。总体而言，肺炎链球菌菌株被认为对青霉素敏感，抗菌药物耐药性有限。

结论

与使用 PCV7 的儿童相比，PCV13 实施后儿童的肺炎链球菌携带率较低。虽然有所减少，但 PCV13 疫苗接种儿童的疫苗血清型定植仍然持续。

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