铁催化的内炔烃与硫代水杨酸的分子间氢硫基化反应，以及串联的分子内环化反应。

Iron-Catalyzed Intermolecular Hydrothiolation of Internal Alkynes with Thiosalicylic Acids, and Sequential Intramolecular Cyclization Reaction.

机构信息

Department of Chemistry, College of Humanities & Sciences, Nihon University , Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.

出版信息

Org Lett. 2017 Aug 18;19(16):4299-4302. doi: 10.1021/acs.orglett.7b01953. Epub 2017 Aug 7.

DOI:10.1021/acs.orglett.7b01953

PMID:28783361

Abstract

We demonstrate the iron-catalyzed intermolecular coupling of internal alkynes and thiosalicylic acid derivatives. The reaction was effectively catalyzed by the Fe(acac)/1,10-phenanthroline catalyst in toluene/HFIP (hexafluoroisopropyl alcohol) as the reaction solvent and afforded several types of 1,3-oxathiine derivatives in moderate to high yields through the intermolecular hydrothiolation and sequential intramolecular cyclization.

摘要

我们展示了铁催化的内炔烃和硫代水杨酸衍生物的分子间偶联反应。该反应在甲苯/ HFIP（六氟异丙醇）作为反应溶剂中，由 Fe(acac)/1,10-菲咯啉催化剂有效地催化，通过分子间氢硫代和连续的分子内环化，以中等至高产率得到了几种 1,3-氧硫杂环戊烷衍生物。